A 2025 study found that termination of federal research grants disrupted about 1 in 30 clinical trials funded by the National Institutes of Health.
November 18, 2025
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statistical
Proportion of NIH-funded clinical trials affected by grant terminations.
A 2025 study found that more than 74,000 patients were enrolled in clinical trials that were interrupted by termination of National Institutes of Health grants.
November 18, 2025
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statistical
Number of participants enrolled in NIH-funded clinical trials affected by grant terminations.
A 2025 study found that the National Institutes of Health terminated grants for 383 clinical trials between February 28, 2025 and August 15, 2025 out of 11,008 clinical trials it funded during that period.
November 18, 2025
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statistical
Counts of NIH-funded clinical trials and grant terminations within a specified date range in 2025.
A 2025 study found that more than 14% of infectious disease trials, about 6% of respiratory illness trials, and about 5% of cardiovascular trials funded by the National Institutes of Health had their funding terminated.
November 18, 2025
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statistical
Breakdown of NIH-funded clinical trial terminations by disease focus area in 2025.
A 2025 study published in JAMA Internal Medicine found that 383 clinical trials funded by the National Institutes of Health between 2025-02-28 and 2025-08-15 experienced funding interruptions, representing nearly 1 in 30 (about 383 of 11,008) NIH-funded clinical trials during that period.
August 15, 2025
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statistical
Analysis of NIH-funded clinical trials over a specific 2025 period to quantify funding interruptions.
A 2025 study found that clinical trials with interrupted NIH funding included 74,311 participants enrolled in trials that were active and not recruiting, a status in which participants may have been receiving interventions.
August 15, 2025
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statistical
Participant enrollment count in NIH-funded trials whose funding was interrupted during the 2025 study window.
A 2025 study reported that among NIH-funded clinical trials whose funding was interrupted, over 36% had been completed, about 35% were recruiting, about 11% were active but not recruiting, about 14% were active but not yet recruiting, and the remaining trials were enrolling by invitation.
August 15, 2025
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statistical
Status distribution of NIH-funded clinical trials at the time their funding was interrupted in the 2025 study window.
A 2025 study found that NIH-funded clinical trials conducted outside the United States were disproportionately affected by funding interruptions, that the U.S. Northeast had the highest regional rate of interrupted trials within the United States, and that more than 115 interrupted trials studied cancer while 97 interrupted trials studied infectious disease.
August 15, 2025
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statistical
Geographic and condition-specific counts and patterns among NIH-funded clinical trials with interrupted funding during the 2025 study window.
The gut–brain connection refers to two-way communication between the digestive system and the brain through nerves, hormones, and gut microbes.
January 01, 2025
high
definition
Concept used to explain how psychological factors and physiological gut processes interact in conditions like irritable bowel syndrome and symptom perception.
A 2023 National Institutes of Health RECOVER study of 3,659 participants identified eight distinct long COVID symptom trajectories measured between three and 15 months after infection.
January 01, 2023
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statistical
The RECOVER initiative by the National Institutes of Health analyzed participant-reported symptoms over time to classify patterns of long COVID.
The 2023 National Institutes of Health RECOVER study sample was 69% female and 99.6% of participants were studied during the Omicron variant era.
January 01, 2023
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statistical
Demographic and temporal composition of the RECOVER study cohort.
A 2023 National Institutes of Health Researching COVID to Enhance Recovery (RECOVER) study of long COVID identified eight distinct symptom trajectory patterns experienced by participants.
January 01, 2023
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statistical
The RECOVER initiative is an NIH research program studying long-term effects of COVID-19.
A 2023 National Institutes of Health RECOVER long COVID study included 3,659 participants, of whom 69% were female and 99.6% were studied during the Omicron variant era.
January 01, 2023
high
statistical
Participant composition and variant-era context provide demographic and temporal framing for the study's findings.
The U.S. National Institutes of Health states that vitamin D3 is produced in the body after exposure to sunlight and is found in animal-derived foods, while vitamin D2 is derived from plant or fungal sources.
high
definition
General nutrient source and synthesis information cited to the National Institutes of Health in the article.
The National Institutes of Health identifies possible autism risk factors that include prenatal exposure to pesticides or air pollution, extreme prematurity or low birth weight, certain maternal health conditions, and older parental age at conception.
high
risk_factors
Potential risk factors cited by a major research funding agency.