clinical research

A 2025 16-week double-blind trial by Rutgers University found that adults taking 2,000 mg/day metformin while exercising had smaller improvements in vascular insulin sensitivity and aerobic fitness than adults who exercised without metformin.

A 2025 study published in JAMA Internal Medicine found that 383 clinical trials funded by the National Institutes of Health between 2025-02-28 and 2025-08-15 experienced funding interruptions, representing nearly 1 in 30 (about 383 of 11,008) NIH-funded clinical trials during that period.

A 2025 study found that clinical trials with interrupted NIH funding included 74,311 participants enrolled in trials that were active and not recruiting, a status in which participants may have been receiving interventions.

A 2025 study reported that among NIH-funded clinical trials whose funding was interrupted, over 36% had been completed, about 35% were recruiting, about 11% were active but not recruiting, about 14% were active but not yet recruiting, and the remaining trials were enrolling by invitation.

A 2025 study found that NIH-funded clinical trials conducted outside the United States were disproportionately affected by funding interruptions, that the U.S. Northeast had the highest regional rate of interrupted trials within the United States, and that more than 115 interrupted trials studied cancer while 97 interrupted trials studied infectious disease.