A 2025 16-week double-blind clinical trial by researchers at Rutgers University enrolled 72 adults at risk for metabolic syndrome and assigned them to four groups performing high- or low-intensity exercise with either placebo or 2,000 mg/day metformin.
October 01, 2025
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temporal
Trial design, sample size, population at risk for metabolic syndrome, exercise intensity, and metformin dosage.
A 2025 16-week double-blind trial by Rutgers University found that adults taking 2,000 mg/day metformin while exercising had smaller improvements in vascular insulin sensitivity and aerobic fitness than adults who exercised without metformin.
October 01, 2025
high
temporal
Comparison of exercise outcomes with and without concurrent metformin use.