Induced regulatory T cells (iTregs) can be generated from conventional T cells by inducing expression of the transcription factor Foxp3 using drugs and signaling molecules, but many induced iTregs lose Foxp3 expression rapidly and have limited durability.
October 06, 2025
high
conceptual
Laboratory methods for generating Tregs and a known limitation
A 2025 study by researchers at the University of Osaka reported a protocol combining signaling molecules and other compounds that increases Foxp3 expression in induced regulatory T cells (iTregs), induces epigenetic modifications associated with Treg identity, and produced iTregs that maintained Foxp3 expression and provided immune-suppressive effects in mouse models for at least six weeks.
October 06, 2025
high
study
Core experimental findings on a method to stabilize iTregs reported in 2025