The ANGPTL3 gene contributes to the production of cholesterol and triglycerides in the liver, and disabling or 'knocking out' ANGPTL3 in the liver reduces cholesterol and triglyceride production.
November 08, 2025
high
temporal
Biological mechanism targeted by gene-editing approaches to lower lipids.
Gut bacteria in the small intestine can metabolize dietary fructose before that fructose reaches the liver.
medium
physiological
Microbial metabolism of sugars in the small intestine can reduce the amount of sugar delivered to the liver.
Dietary fibers that feed gut microbes (prebiotics) can decrease the amount of dietary fructose reaching the liver and thereby have the potential to reduce hepatic fat accumulation and oxidative stress associated with early fatty liver disease.
medium
clinical potential
Prebiotic fibers support microbial consumption of fructose in the gut, which may lower liver exposure to fructose and its downstream metabolic effects.