The study sample was limited to generally healthy, largely well-educated participants and did not include individuals already showing signs of dementia, which constrains generalizability of the findings to clinical populations.
high
temporal
Methodological limitation affecting applicability to people with dementia or less-educated populations.
Cerebral small vessel disease is a condition that damages the brain's tiny blood vessels and is associated with aging, high blood pressure, and dementia.
high
medical
Describes the nature and common risk factor associations of cerebral small vessel disease.
Mild cognitive impairment (MCI) is a clinical stage between normal aging and dementia characterized by measurable cognitive decline that can still allow for independent living in many cases.
high
clinical
Definition and clinical significance of MCI