Antibiotics, psycholeptics, antidepressants, proton pump inhibitors (PPIs), beta blockers, and benzodiazepine derivatives can alter the composition of the human gut microbiome, and medication-associated microbial changes can persist for years after use.
high
statistical
Multiple commonly prescribed drug classes have been associated with lasting shifts in gut microbial composition.
Antidepressants are medications used to treat depression, anxiety, and other health conditions.
high
general
Definition of the medication class
Different antidepressants can cause a wide range of physiological side effects, including changes in weight, heart rate, blood pressure, and total cholesterol.
high
general
Variability in side-effect profiles across antidepressant drugs
Kidney function, liver function, electrolyte levels, and heart rhythm are generally not majorly affected by most antidepressants.
medium
general
Aspects of organ and physiological monitoring that are often less impacted by antidepressant treatment
Antidepressant effects and side effects vary between individuals depending on factors such as a person's metabolism, age, and concurrent medications, so tailoring treatment and careful monitoring are recommended.
high
general
Principles for individualized prescribing and monitoring of antidepressant therapy