A 2025 10-week study led by researchers at McGill University of 92 healthy adults aged 65 or older found that doing rigorous cognitive training for 30 minutes per day increased acetylcholine levels by 2.3% in the anterior cingulate cortex.
October 22, 2025
high
temporal
Acetylcholine was measured in the anterior cingulate cortex using PET imaging to assess the effect of targeted cognitive training.
Research on SuperAgers has identified two neurobiological mechanisms linked to preserved memory in advanced age â 'resistance' (absence or low accumulation of amyloid and tau protein plaques/tangles) and 'resilience' (presence of amyloid and tau without evident cognitive impairment) â and has associated SuperAgers with reduced cortical thinning, a thicker anterior cingulate cortex, greater numbers of von Economo neurons, and larger entorhinal neurons.
high
neuroscience
Neurobiological features and proposed mechanisms underlying preserved memory in very old adults labeled as SuperAgers.