A 2024 study led by the University of Oxford in collaboration with Yale University and the University of Cambridge published in BMJ Evidence-Based Medicine analyzed data from more than 500,000 participants from the UK Biobank and the U.S. Million Veteran Program and from over 2.4 million participants across 45 studies to investigate links between genetically predicted alcohol consumption, alcohol use disorder, and dementia risk.
January 01, 2024
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Study design and sample sizes used to assess genetic and observational links between alcohol use and dementia
A 2024 genetic-analysis study reported that individuals with a doubled genetic risk for alcohol use disorder had a 16% higher risk of dementia.
January 01, 2024
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Result from Mendelian-randomization/genetic-prediction analyses linking alcohol-related genetic predisposition to dementia risk
A 2024 genetic-analysis study reported that a threefold increase in weekly alcoholic drinks (genetically predicted) was associated with a 15% greater risk of dementia.
January 01, 2024
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Result quantifying association between genetically predicted higher alcohol consumption and dementia risk
A 2024 study concluded that genetic evidence offers no support for a protective effect of light or moderate alcohol consumption on brain health and instead suggests that even low levels of alcohol consumption may increase the risk of dementia.
January 01, 2024
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Interpretation of genetic and observational evidence regarding alcohol consumption and dementia risk