In 2003 Shimon Sakaguchi linked prior findings by showing that the Foxp3 gene controls the development of regulatory T cells, and that regulatory T cells act to suppress other T cells that would otherwise overreact.
January 01, 2003
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Functional linkage between a specific gene and the development and immunosuppressive role of regulatory T cells.
Central tolerance is the immunological process in which the thymus eliminates developing T cells that would react against the body's own tissues.
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Definition of a fundamental immune system tolerance mechanism.
CAR-T (chimeric antigen receptor T-cell) therapy was originally developed to treat hard-to-treat blood cancers by engineering a patient’s T cells to recognize and eliminate malignant B cells.
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Origins and therapeutic target of CAR-T therapy
The CAR-T therapy process typically involves extracting a patient’s T cells, genetically programming those T cells to target specific B cells, expanding millions of modified T cells in the lab, administering lymphodepleting chemotherapy to the patient, and then infusing the engineered T cells back as a form of "living drug."
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Standard clinical/manufacturing workflow for CAR-T treatments