Individuals who carry two copies of the APOE4 allele (APOE4/4) have about ten times the typical risk of developing Alzheimer's disease; APOE4/4 carriers constitute about 2% of the general population but represent about 15% of people diagnosed with Alzheimer's disease.
October 29, 2025
high
epidemiological
APOE4/4 genotype-associated prevalence and relative risk for Alzheimer's disease.