Stanford study reverses Type 1 diabetes in mice
Stanford School of Medicine researchers report in the Journal of Clinical Investigation that a conditioning regimen to reset immunity, followed by bone marrow and donor islet-cell transplants, prevented or reversed Type 1 diabetes in mice. The team achieved 100% success in 19 pre‑diabetic mice and cured nine mice with established disease, with no major side effects reported, and say the approach could pave the way for human studies.
📌 Key Facts
- Study published in the Journal of Clinical Investigation and announced via Stanford press release.
- Protocol used low-dose radiation and anti‑T‑cell antibodies to enable 'mixed chimerism' (recipient and donor immune cells).
- All 19 pre‑diabetic mice were protected from developing diabetes after treatment.
- All 9 mice with long‑standing Type 1 diabetes were cured following combined stem‑cell and donor islet transplantation.
- Researchers reported no major side effects or immune depletion in treated mice.