The United States switched in the 1990s from whole-cell pertussis vaccines to acellular pertussis vaccines; acellular vaccines cause fewer side effects but generally provide shorter-lasting immunity than whole-cell vaccines.
January 01, 1990
high
temporal
Vaccine formulation change and trade-off between side effects and duration of protection.
In the 1990s, the United States switched from whole-cell pertussis vaccines to acellular pertussis vaccines; acellular vaccines are associated with fewer side effects but generally provide shorter-lasting protection against infection, contributing to waning immunity over time.
high
vaccine-history
Change in vaccine formulation and its implications for duration of immunity.