A regulatory agency's effectiveness depends on the quality and retention of its workforce, and high staff turnover can impair the agency's functionality.
November 04, 2025
high
general
General organizational principle referenced in reporting about the U.S. Food and Drug Administration (FDA).
Reduced predictability in regulatory decision-making can prompt pharmaceutical and biotechnology companies to move investment dollars elsewhere.
November 04, 2025
high
general
Describes how industry investment decisions are influenced by the perceived predictability of regulatory agencies such as the FDA.
Staffing shortfalls in a regulatory agency can lead either to slower approval processes or to decreased thoroughness of reviews, and either outcome can create risks to public health.
November 04, 2025
high
general
General consequence of reduced staffing levels in regulatory review organizations, as discussed in industry analyses.
The U.S. Food and Drug Administration recognized depression as a potential side effect of finasteride in 2011 and recognized suicidality as a potential side effect in 2022.
January 01, 2011
high
temporal
Regulatory labeling acknowledgments by the FDA regarding neuropsychiatric adverse effects of finasteride.
The U.S. Food and Drug Administration recorded 18 suicides linked to finasteride in 2011.
January 01, 2011
high
statistical
A reported count of suicide cases associated with finasteride in FDA records for 2011.
The U.S. Food and Drug Administration (FDA) has stated that 'black box' warnings on menopausal hormone treatments have discouraged many women from using those therapies.
high
general
Regulatory labeling (so-called 'black box' warnings) can influence patient and clinician decisions about medication use.