Systemic hormone therapy is designed to circulate hormones throughout the bloodstream and is administered orally or via transdermal methods such as patches, sprays, or gels; systemic therapy provides whole-body symptom relief but generally carries higher systemic risk than local therapy, and systemic options include estrogen-only, progesterone-only, or combined regimens.
high
administration
Describes systemic routes, scope of benefit, relative risk, and regimen types for hormone therapy.