Mpox is primarily spread through close, intimate contact with symptomatic people, mainly during sexual activity, and can also be transmitted through close personal contact such as massage or cuddling, within households, or by sharing personal items.
October 17, 2025
high
transmission
Modes of person-to-person transmission for mpox described in public health guidance.
Public health guidance indicates that receiving both doses of the JYNNEOS vaccine provides the best protection against mpox.
October 17, 2025
high
prevention
Vaccine regimen recommendation for best protection against mpox.