The U.S. opioid crisis has been linked to approximately 900,000 deaths in the United States from 1999 through 2025, including deaths involving heroin and illicit fentanyl.
November 14, 2025
high
temporal
Aggregate mortality count attributed to the U.S. opioid crisis over the period beginning in 1999 and reported through 2025.
Approximately 900,000 deaths in the United States have been connected to the opioid crisis since 1999, including deaths from heroin and illicit fentanyl.
November 14, 2025
high
statistical
Cumulative mortality estimate attributable to the broader opioid epidemic over a multi-decade period.
Public-health reporting attributes approximately 900,000 deaths in the United States to the opioid crisis (including deaths from heroin and illicit fentanyl) for the period since 1999.
November 14, 2025
high
temporal
Aggregate mortality estimate for the U.S. opioid crisis covering 1999 through the reporting date.
Since 1999, approximately 900,000 deaths in the United States have been linked to opioids, including deaths involving heroin and illicit fentanyl.
January 01, 1999
high
temporal
Cumulative mortality estimate associated with the U.S. opioid epidemic starting in 1999.