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Connecticut Classifies ‘Gas Station Heroin’ Tianeptine as Schedule I Drug

Connecticut has become the latest state to crack down on tianeptine, often marketed as 'gas station heroin,' by classifying it as a Schedule I controlled substance effective Wednesday, amid a broader nationwide push to restrict the drug. The move, announced by Lt. Gov. Susan Bysiewicz, targets tianeptine products sold in gas stations, vape shops, convenience stores and online under brand names like Tianaa, ZaZa, Neptune’s Fix, Pegasus and TD Red, which officials say have been falsely marketed as safe remedies for pain, anxiety and depression and even packaged with 'candy-like' flavors that appeal to youth. The FDA and DEA warn that tianeptine, a tricyclic antidepressant never approved as a dietary supplement in the U.S., can be more potent than morphine and other opioids at higher doses and has been linked to severe sedation, respiratory depression and death. Alongside tianeptine, Connecticut also scheduled kratom (Mitragyna speciosa and 7‑hydroxymitragynine), Bromazolam, Flubromazolam, Nitazenes and Phenibut, while FDA Commissioner Martin Makary and emergency physician Dr. Robert Schwaner are publicly pressing for tighter national regulation, arguing the drug’s opioid-like action and withdrawal potential mirror heroin and other addictive opioids.

Public Health and Drug Policy State-Level Drug Regulation

📌 Key Facts

  • Connecticut has classified tianeptine as a Schedule I controlled substance effective Wednesday, joining at least 14 other states in banning or tightly restricting the drug.
  • Tianeptine products, sold under names such as Tianaa, ZaZa, Neptune’s Fix, Pegasus and TD Red, have been widely available at U.S. gas stations, convenience stores, vape shops and online.
  • The FDA and DEA state that tianeptine misuse can cause severe sedation, respiratory depression and death, and Dr. Robert Schwaner notes it acts on mu‑opioid receptors similarly to heroin and other opioids.
  • Connecticut simultaneously scheduled kratom (Mitragyna speciosa and 7‑hydroxymitragynine), Bromazolam, Flubromazolam, Nitazenes and Phenibut, citing addiction and youth‑safety concerns.
  • FDA Commissioner Martin Makary recently warned in a public letter that tianeptine use is a 'dangerous and growing health trend' posing serious risks to America’s youth.

📊 Relevant Data

From 2015 to 2023, there were 892 single-substance tianeptine exposures reported to US poison centers, with the rate of exposures increasing 1,400% over this period.

Tianeptine Exposures Reported to United States Poison Centers, 2015-2023 — PubMed

The majority of tianeptine exposures reported to poison centers from 2000 to 2017 occurred among persons aged 21–40 years, accounting for approximately 57% of calls.

Characteristics of Tianeptine Exposures Reported to the National Poison Data System — United States, 2000–2017 — CDC

Males accounted for 55.77% of tianeptine misuse cases in a systematic review of 52 cases from 2014 to 2024, with significant regional variations showing 76.92% of cases in North America.

Gas station heroin- tianeptine and its impact: a systematic review — PMC

Individuals aged 50 years and older were 1.70 times more likely to experience major effects from tianeptine exposure and 1.43 times more likely to require medical admission compared to younger individuals, based on 2015-2023 data.

Tianeptine Exposures Reported to United States Poison Centers, 2015-2023 — PubMed

In Alabama, after enacting legislation to regulate tianeptine as a controlled substance in 2021, the tianeptine exposure rate decreased by 74.6% from 2021 to 2023, while rates in other southern states continued to increase.

Tianeptine Exposures Reported to United States Poison Centers, 2015-2023 — PubMed

Tianeptine exposure rates were highest in the US South, with Alabama's rate increasing by 1,413.7% from 2018 to 2021 before the ban.

Tianeptine Exposures Reported to United States Poison Centers, 2015-2023 — PubMed

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